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MaioRegen

MaioRegen – a new therapeutic concept, inspired by nature and shaped by nanotechnology

MaioRegen is a three-dimensional matrix which mimics the entire osteo-cartilaginoustissue : cartilage, tide mark and sub-chondral bone.

It is a monolithic, multi layer scaffold. The superficial layer consists of deantigenated type 1 equine collagen and resembles the cartilaginous tissue, while the lower layer consists mostly of magnesium enriched Hydroxyapatite (Mg-HA) and simulates the sub-chondral bone structure. The middle layer, composed of Mg-HA and collagen, reproduces the tide mark.

How does MaioRegen work?

It provides a biomimetic osteochondral scaffold which guides and promotes bone and cartilage tissue restoration by inducing selective differentiation of the body’s own bone marrow or synovial fluid derived progenitor cells into osteocytes, in the sub-chondral layer and chondrocytes in the cartilage layer.The experimental study results show how MaioRegen, once implanted, is able to integrate with surrounding tissues and guarantee the regeneration of the entire damaged

The experimental study results show how MaioRegen, once implanted, is able to integrate with surrounding tissues and guarantee the regeneration of the entire damaged osteo-chondral tissue, with the formation of well structured bone tissue and hyaline like cartilaginous tissue.

The adhered progenitor cells proliferate, differentiate and synthesize bone and cartilage matrix according to the organic mineral gradient found inside the scaffold. The progressive reabsorption of MaioRegen and the simultaneous cell mediated remodelling favour the complete regeneration of the osteo-cartilagenous tissue.

More videos on how the product can be used can be found here Finceramica

 

 

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