Customer Services: +44 (0) 114 345 0000 | Reception: +44 (0) 114 345 3200

Products

Orthobiologics

MaioRegen

MaioRegen – a therapeutic concept, inspired by nature and shaped by nanotechnology

MaioRegen is a three-dimensional matrix which mimics the entire osteo-cartilaginoustissue : cartilage, tide mark and sub-chondral bone.

It is a monolithic, multi layer scaffold. The superficial layer consists of deantigenated type 1 equine collagen and resembles the cartilaginous tissue, while the lower layer consists mostly of magnesium enriched Hydroxyapatite (Mg-HA) and simulates the sub-chondral bone structure. The middle layer, composed of Mg-HA and collagen, reproduces the tide mark.

How does MaioRegen work?

It provides a biomimetic osteochondral scaffold which guides and promotes bone and cartilage tissue restoration by inducing selective differentiation of the body’s own bone marrow or synovial fluid derived progenitor cells into osteocytes, in the sub-chondral layer and chondrocytes in the cartilage layer.The experimental study results show how MaioRegen, once implanted, is able to integrate with surrounding tissues and guarantee the regeneration of the entire damaged

The experimental study results show how MaioRegen, once implanted, is able to integrate with surrounding tissues and guarantee the regeneration of the entire damaged osteo-chondral tissue, with the formation of well structured bone tissue and hyaline like cartilaginous tissue.

The adhered progenitor cells proliferate, differentiate and synthesize bone and cartilage matrix according to the organic mineral gradient found inside the scaffold. The progressive reabsorption of MaioRegen and the simultaneous cell mediated remodelling favour the complete regeneration of the osteo-cartilagenous tissue.

MaioRegen is available in three different configurations tailored meet individual patient needs :

MaioRegen Prime for the treatment of osteochondral lesions with severely compromised subchondral bone

MaioRegen Slim for the treatment of osteochondral lesions with slightly compromised subchondral bone

MaioRegen Chondro+ for the treatment of cartilage lesions

There is a large body of evidence supporting the effectiveness of MaioRegen with over 28 clinical papers with the latest being a $4M pan European, multi centre,  randomised controlled study comparing MaioRegen to Microfracture. This showed that particularly with Deep lesions, sport active patients or Osteochondritis Dissecans there is a statistically significant improved outcomes (IKDC subjective scoring) for MaioRegen compared to Microfracture.  Overall two-thirds of patients treated with MaioRegen show a statistically significant superiority in IKDC subjective scoring compared to Microfracture. You can find the full paper here Knee Surgery, Sports Traumatology, Arthroscopy

More videos on how the product can be used can be found here Finceramica

An interesting patient story video can be found on our YouTube Dancer recovers with help of MaioRegen

 

Related Downloads