MedTech Innovation

Technology Research Business Area

Our Vision

To introduce across the globe innovative treatments to joint-related conditions that both improve patient outcomes and reduce costs to healthcare services and society as a whole

Our Purpose

To achieve our vision through collaborative development that attracts grant and other funding to allow us to co-develop and protect the technology associated with the innovative treatments then to launch into the clinics and markets across the world

Our Story

Although JRI Orthopaedics is a traditional manufacturing company, we do have a long-standing history innovation. In Technology Research we have a modern and networked approach to MedTech innovation that allows us to contribute at the edges of science and technology in the area of implantable MedTech – overcoming two major hurdles facing us when we innovate:

  1. Rapidly changing knowledge and understanding in technologies associated with medicine in general and orthopaedic surgery in particular
  2. Providing resources to early technology developments with all their associated risks

Our Networked Approach

We use a networked, collaborative approach that reduces risks and dramatically increase our chances of success in two ways: A) de-risk technically by collaborating and co-developing with Universities and commercial partners that have skills in areas in which we are not experts ourselves; and B) de-risk financially by ensuring our consortia are funded through grants, in particular through Innovate UK and Horizon 2020 (Europe).

Our Targeted Approach

The field in which we work, MedTech Innovation, is complex especially if the technology is to be implanted – these complications arise from: 1) the rapidly changing science and technology underpinning implantable MedTech; and 2) the ever-increasing demands from the global regulations. Our approach is to strategically target three key areas of focus:

  1. Joint Surface Regeneration – regenerating joints and not replacing them
  2. The Bone/Implant Interface – where our implants meet the skeleton
  3. In-theatre Manufacture – finishing implants within the sterile field

We have taken on the co-develop of many new technologies to allow us to deliver these three areas of focus, this includes; novel biomaterials, advanced manufacturing processes, surfaces and coating that elicit enhanced biological responses, new treatment approaches and regenerative medical products. We work with leading clinical and non-clinical academics from the top Universities in the world and we are proud to collaborator with world-class companies from around UK, Europe and the rest of the world.

All of our developments are planned from the outset to get to market as rapidly and as efficiently as possible, which we do because we have access to global markets. We have a start-up company called Ortheia that helps us, and more importantly, our academic and commercial partners, to get to market. More information can be found on its web-site, Ortheia.com – perhaps Ortheia can help you, go have a look

Our Partners

Our Grant-giving Body Partners that have Funded Our Projects, include:

Grant-giving BodyLogo
Innovate UKInnovate UK
Horizon 2020, European CommissionHorizon 2020 Logo
UKRI - EPSRCUKRI-EPSRC Logo
UKRI - BBSRCUKRI-BBSRC Logo
Framework 7, European CommissionFramework 7 Logo
Technology Strategy Board, UK GovernmentTechnology Strategy Board Logo

Our Academic Partners, include:

UniversityLogo
University of CambridgeUniversity of Cambridge logo
Karolinkska Institutet, Stockholm, SwedenKarolinska Institutet logo
Newcastle UniversityNewcastle University logo
Imperial College, LondonImperial College, London logo
UCL, University College LondonUCL logo
University of SheffieldUniversity of Sheffield logo
University of LeedsUniversity of Leeds logo
University of LiverpoolUniversity of Liverpool logo
University of St AndrewsUniversity of St Andrews logo
University of Applied Sciences and Arts, Northwestern SwitzerlandUniversity of Applied Sciences and Arts Northwestern Switzerland
Universidade de Évora, PortugalUniversidade de Évora logo
University of Medicine and Pharmacy, Iuliu Haţiegan, Cluj-Napoca, RomaniaIuliu Haţieganu University of Medicine and Pharmacy Cluj-NapocaIuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca logo

Our Commercial Partners, inlcude:

Commercial PartnerLogo
SpheriTech, UKSpheriTech logo
Glass Technology Services, UKGTS logo
BCT GmbH, GermanyBCT logo
3D Systems3D Systems Logo
Bionica Tech srl, ItalyBionica Tech SRL logo
Corep, ItalyCOREP Logo
ORLA Protein Technologies, UKOrla Protein Technologies logo
Surgical InnovationsSurgical Innovations logo
Sagetis Biotech, SpainSagetis Biotech logo
M Squared Lasers, UKM Squared logo
Metron Advanced Engineering, UKAdvanced Equipment logo
VitriTechVitriTech logo

Our Non-University Research and Technology Development Organisation Partners, include:

Research and Technology Development OrganisationLogo
TWI, UKTWI logo
Cell and Gene Therapy Catapult, UK
LEITAT, SpainLEITAT logo
High Value Manufacturing Catapult, UKHigh Value Manufacturing Catapult logo
Manufacturing Technology Centre, UKManufacturing Technology Centre logo

Areas of Interest

  • Key Focus Area - Joint Surface Regeneration

    The development of innovative implants and novel biomaterials that can regenerate the joint surface in early-stage joint disease

  • Key Focus Area - Bone/Implant Interface

    Developments to enhance the interface between our implants and the host bone tissues to improve the quality of osseointegration and accelerate the time to
    acheiving it. Using technologies that including: additive manufacturing, bioactive glasses and protein enhancements

  • Key Focus Area - In-Theatre Manufacturing

    Development of technologies that allow an implant to be completed or manufactured in its entirety within the sterile field of the operating theatre. Based on technologies such as: 3D scanning, additive manufacture, and protein and inorganic surface enhancements

Current and Previous Projects

Title “SWIFT: Innovative Arthroscopic Approach for Regenerative Treatment of the Hip”
Codename SWIFT
Overview This exciting business-led project brings together industry and academia, with two commercial partners, JRI Orthopaedics (lead) and Salthaus, and the University of Sheffield. They will open new opportunities to treat hip diseases. Today there are treatments that can regrow the joint surface (known as regenerative medicine); these are only used in the knee because accessing the hip is surgically more difficult. Using a technology that JRI has patented, a surgeon can use a key-hole approach to access the hip; prepare the joint surface accurately (critical to final success of the treatment) and then rapidly inject the implant directly into the prepared area.
Lead JRI Orthopaedics
Partners JRI Orthopaedics, Salthaus, University of Sheffield
Grant-Giving Body  Innovate UK
Start Year 2017
Status Current
Budget £911,574
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=103856

Title “ADROIT – Arthroscopically-Deliverable Regenerative Osteochondral Implant Technology”
Codename ADROIT
Overview In this project the three partners (two SMEs: JRI and Spheritech, and University of Cambridge) will for the first time ever develop a biomaterial that can be implanted using ‘keyhole’ (arthroscopy) or open surgery, specifically to regrow the joint surface in the early-stages OA.
Lead JRI Orthopaedics
Partners JRI Orthopaedics, Spheritech, University of Cambridge
Grant-Giving Body  Innovate UK
Start Year 2017
Status Current
Budget £780,956
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=102836

Title “SEAMLESS – Digitally-Enabled, Automated Post-Processing for AM”
Codename SEAMLESS
Overview The SEAMLESS project represents a major technical and commercial advance in the area of post processing for additive manufacturing. The poor surface quality for AM parts has been a major barrier for full process adoption, which will be addressed in this project. The SEAMLESS solution combines a number of surface finishing and post processing technologies including super finishing, laser peening, laser polishing and adaptive linishing, together with in-process inspection and simulation tools to address the post processing requirement for the widestrange of end-users.
Lead Toolroom Technology
Partners JRI Orthopaedics, Toolroom Technology, Meggitt Aerospace, ATS Applied Tech Systems, Zeeko, Ether NDE, Manufacturing Technology Centre
Grant-Giving Body  Innovate UK
Start Year 2017
Status Current
Budget £375,776
Duration 36 Months
Details http://gtr.ukri.org/projects?ref=103274

Title “OrthoSculpt”
Codename OrthoSculpt
Overview OrthoSculpt looks to develop an innovative manufacturing technique that should recuce the cost of orthopaedic implants, which will allow more patients to have the uncemented version. This technique is based on a novel technology owned by TWI, a UK research organisation, called Surfi-Sculpt®. With Surfi-Sculpt, a porous surface can be added to an implant by ‘moving’ the metal on its surface using an electron beam.
Lead JRI Orthopaedics
Partners TWI
Grant-Giving Body  Innovate UK
Start Year 2017
Status Delivered
Budget £190,177
Duration 12 Months
Details http://gtr.ukri.org/projects?ref=132496

Title “Porous Impant Bioactive Coating (PIBaC)”
Codename PIBaC
Overview After years of work funded by Innovate UK, a UK partnership of two SMEs, JRI Orthopaedics and GTS are looking to scale up a new functional coating for orthopaedic implants. This will combine two successful technologies: 1) bioactive glasses and 2) 3D printed implants with complex shapes. This project will enable JRI to expand the range of its joint replacements to include highly-complex implants that are tailored to an individual.
Lead JRI Orthopaedics
Partners JRI Orthopaedics, Glass Technology Services
Grant-Giving Body  Innovate UK
Start Year 2016
Status Delivered
Budget £149,894
Duration 12 Months
Details http://gtr.ukri.org/projects?ref=132368

Title “Flexible and automated finishing and post-processing cell for high value AM components – FlexiFinish”
Codename FlexiFinish
Overview The FlexiFinish project addresses the significant challenges faced by industry surrounding the ability to finish surfaces on complex parts, in a controlled and cost effective manner. This is also becoming a significant barrier to the wider uptake of additive parts within the Aerospace industry and beyond. In order to address this, the FlexiFinish project will create a fully automated cell which includes a number of finishing (laser polishing and adaptive linishing) and post processing technologies (shot peening).
Lead Toolroom Technology
Partners JRI Orthopaedics, Toolroom Technology, Alstom Power, Meggitt Aerospace, Sandwell, Manufacturing Technology Centre
Grant-Giving Body  Innovate UK
Start Year 2016
Status Delivered
Budget £870,323
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=102576

Title “Arthroscopic Regenerative Medicine for Early-Stage Treatment of OA”
Codename ARMOURY
Overview In this project JRI worked with University Medical Center Utrecht (UMCU), The Netherlands and the Cell and Gene Therapy Catapult (CGT), UK, to develop a new treatment of OA in the hip and take it to market. This involved catching the disease early when it appears as a distinct lesion. JRI has developed ‘Hummingbird’, a system that can get into the complex anatomy of the hip and precisely cut out patches of diseased tissue. Then treating these patches with a cell-based treatment developed by UMCU and successfully used to treat OA in the knee.
Lead JRI Orthopaedics
Partners JRI Orthopaedics, University Medical Center Utrecht (Informal Partner), Cell and Gene Therapy Catapult (Informal Partner)
Grant-Giving Body  Horizon 2020, European Commission
Start Year 2016
Status Delivered
Budget €71,429
Duration 12 Months
Details https://cordis.europa.eu/project/rcn/205137_en.html

Title “Forging the standards which will shape the UK’s AM sector (ANVIL)”
Codename ANVIL
Overview Additive Manufacturing (AM) has the potential to revolutionise the design, production and supply of parts, but exploitation has been limited. A major challenge for industry is to understand the true capability of the new techniques – especially making comparisons between machine platforms. The ANVIL project will overcome this issue
Lead 3TRPD
Partners JRI Orthopaedics, 3T RPD, K-Tech Suspension, Rolls-Royce Controls and Data Services, Limitstate, Magna Parva, Manufacturing Technology Centre, TWI
Grant-Giving Body  Innovate UK
Start Year 2014
Status Delivered
Budget £892,065
Duration 30 Months
Details http://gtr.ukri.org/projects?ref=101483

Title “Early Stage Regenerative Remediation of hip OA by novel curvilinear arthroscopy”
Codename Regenoscopy
Overview Development of a set of instruments to allow the regeneration of the surface of the human hip using novel powered arthroiscopic instruments for the hip to prepared the joint surface and deliver accurately new regenerative medical products (RMP)
Lead JRI Orthopaedics
Partners JRI Orthopaedics, Surgical Innovations
Grant-Giving Body  Innovate UK
Start Year 2014
Status Delivered
Budget £625,159
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=101596

Title “FASTIC – Femtosecond-pulsed-laser Augment/bioglass Sintering Technique for Implant Customisation”
Codename FASTIC
Overview The aim is to develop new technology to allow surgeons to customise joint replacements at the time of surgery on the rare occasions when there is significant bone loss either from a failed implant that needs to be revised or from bone cancer
Lead Partner JRI Orthopaedics
Partners JRI Orthopaedics, Glass Technology Services, M-Squared Lasers, University of Leeds, University of St Andrews
Grant-Giving Body Innovate UK
Start Year 2014
Status Delivered
Budget £690,188
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=101670

Title “The Direct Manufacturing of Personalised Implants using Selective Laser Melting”
Codename ImplantDirect
Overview The overall aims of the Implant Direct project were to improve the quality of life for patients and reduce the healthcare costs by improving the quality of the implant and reducing recovery time. This was achieved by allowing surgeons to customise implants to the individual patients and the individual trauma, thus reducing the number of revisions, the length of surgery time and the recovery time of the patient.
Lead Partner JRI Orthoapedics
Partners JRI Orthopaedics, BCT, Realizer, LaywerWise, Listemann AG, University of Applied Sciences and Arts, Northwestern Switzerland, University of Medicine and Pharmacy, Iuliu Haţiegan, Cluj-Napoca
Grant-Giving Body Framework 7, European Commission
Start Year 2014
Status Delivered
Budget €1,258,245
Duration 24 Months
Details http://www.implantdirect-project.eu/

Title “Novel 3D coating of bioactive glass and metallic composites”
Codename BioGlaM
Overview The aim is to develop the next generation of coatings for orthopaedic implants such as hip replacements. The new combination glass and metal coatings will have better mechanical stability and faster integration
Lead Partner JRI Orthopaedics
Partners JRI Orthopaedics, Delta-T Devices, Glass Technology Services, 3T RPD, University of Sheffield, The Manufacturing Technology Centre
Grant-Giving Body Innovate UK
Start Year 2013
Status Delivered
Budget £795,108
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=101480

Title “Resorbable Ceramic Biocomposites for Orthopaedics and Maxillofacial Applications RESTORATION”
Codename RESTORATION
Overview In order to deliver on the potential shown by bioceramic composites the combination of mechanical design, materials, processing, clinical delivery and subsequent biological interaction all have to be understood in an integrated and systematic way. The RESTORATION project addressed this underlying research and technological challenge in order to develop new bioceramic products for five SME partner companies
Lead Partner Newcastle University
Partners JRI Orthopaedics, Glass Technology Services, M-Squared Lasers, University of Leeds, University of St Andrews
Grant-Giving Body Framework 7, European Commission
Start Year 2012
Status Delivered
Budget €3,828,359
Duration 48 Months
Details http://restoration-project.eu/

Title “The development of culture conditions to promote the differentiation of hyaline chondrocytes from mesenchymal stem cells”
Codename CHONDRODIFF
Overview Project Aims: [1] To establish culture conditions capable of directing the differentiation of nascent chondrocytes derived from MSC to hyaline, rather than hypertrophic cartilage. [2] To test if the growth factors identified in 1 can be replaced by small molecular weight mimetics or peptidic motifs. [3] To fabricate molecularly engineered variants of the ZT biomaterial scaffold to incorporate the key motifs/peptide motifs identified in 2. [4] To determine if the molecularly engineered biomaterials fabricated in 3 are able to maintain the phenotype of MSC-derived hyaline chondrocytes in vitro. [5] To implement a commercialisation strategy for culture conditions, media compositions and engineered biomaterials derived from this work that are capable of maintaining the phenotype of hyaline chondrocytes
Lead Partner University of Liverpool
Partners JRI Orthopaedics, University of Liverpool
Grant-Giving Body BBSRC
Start Year 2011
Status Delivered
Budget £91,932
Duration 60 Months
Details http://gtr.ukri.org/projects?ref=BB%2FI01666X%2F1

Title “Ultravit”
Codename Ultravit
Overview To develop, evaluate and test a new, marketable, bioactive coating that will meet clinical need.
Lead Partner University of Sheffield
Partners JRI Orthopaedics, University of Sheffield
Grant-Giving Body Technology Strategy Board
Start Year 2011
Status Delivered
Budget £135,218
Duration 24 Months
Details http://gtr.ukri.org/projects?ref=508127